Endocrine Abstracts

The morbidity and mortality associated with long-term diabetic complications continue to rise and will remain a major worldwide health problem in the coming years. Islet cell transplantation has recently emerged as one the most promising therapeutic approaches to improving glycometabolic control in diabetic patients and, in many cases, to obtaining insulin independence. Unfortunately, many flaws still persist that make it impossible for islet transplantation to become the gold...

Introduction: It is known that very-low-calorie-ketogenic-diet (VLCKD) has beneficial effects on body weight in overweight diabetic patients. Adopting this diet with artificial meals or natural foods in type 2 diabetes (T2DM) has been largely studied, and conflicting results have been reported regarding its effects on glycemic profiles, dyslipidemia, and liver function. In fact, the high level of fat content in natural foods could have a negative impact on hepatic steatosis, a...

Background: The incidence of gestational diabetes mellitus (GDM) is increasing worldwide, with considerable impact on the health of both mother and newborn. There is no doubt that screening for GDM between 24 and 28 gestational weeks (GWks) is important to reduce the risk of adverse outcomes; however, there is no clear consensus about the diagnosis and treatment of GDM in early pregnancy.Aims: To evaluate the effect of time of GDM diagnosis (early onset ...

Background: In patients affected with type 2 diabetes mellitus (T2DM) a high prevalence of hypogonadism has been reported, even if there is no consensus on its metabolic and cardiovascular implications, especially according to the type of hypogonadism. The aim of this observational study is to evaluate: (1) the prevalence of different types of hypogonadism in T2DM according to validated criteria from the EMAS study; (2) look for correlations of gonadal status with severity or ...